Because of the high risk, substantial cost and slow pace of new drug discovery and
development, drug repurposing (also called repositioning, redirecting, reprofiling) is …

The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …

Agricultural production is seriously threatened by plant pathogens. The development of new
fungicides with high efficacy and low toxicity is urgently needed. In this study, a series of …

Virtually all Candida species linked to clinical candidiasis are capable of forming highly
resistant biofilms on different types of surfaces, which poses an additional significant threat …

Fungal infections are a major public health problem resulting from the lack of public policies
addressing these diseases, toxic and/or expensive therapeutic tools, scarce diagnostic tests …

There is a consensus that the antifungal repertoire for the treatment of cryptococcal
infections is limited. Standard treatment involves the administration of an antifungal drug …

The emergence of multidrug-resistant fungi is of grave concern, and its infections are
responsible for significant deaths among immunocompromised patients. The treatment of …

A streamlined and efficient approach to the key epoxide intermediate for the asymmetric
synthesis of triazole antifungal agents is presented. This synthesis highlights a P (NMe2) 3 …

Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-
tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and …

To develop novel succinate dehydrogenase (SDH) inhibitors for sustainable crop protection,
a series of dehydroabietyl-diamide-based fungicides (a total of 21) were designed. In vitro …