Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and
promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads …

Olfaction is a major sensory modality involved in real time perception of the chemical
composition of the external environment. Olfaction favors anticipation and rapid adaptation …

Pharmacological activation of the hypothalamic glucagon-like peptide 1 (GLP-1) receptor
(GLP-1R) promotes weight loss and improves glucose tolerance. This demonstrates that the …

Compelling evidence has shown that, besides its putative effect on the regulation of the
gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food …

The regulation of energy balance by the central nervous system (CNS) is a key actor of
energy homeostasis in mammals, and deregulations of the fine mechanisms of nutrient …

Background Sphingolipid-mediated signalling pathways are described as important players
in the normal functioning of neurons and nonneuronal cells in the central nervous system …

The hypothalamus plays a crucial role in regulating feeding behavior in fish. In this Review,
we aim to summarise current knowledge on specific mechanisms for sensing glucose, fatty …

The hypothalamic feeding center plays an important role in energy homeostasis. The
feeding center senses the systemic energy status by detecting hormone and nutrient levels …

An extended series of studies indicate that endogenous phase shifts in circadian neuronal
input signaling to the biological clock system centered within the hypothalamic …

We investigated whether linoleic acid (LA) supplementation could modulate emotional
behavior and microglia-related neuroinflammation. For that, male mice of C57BL/6J genetic …