Advances in cancer diagnosis: Bio-electrochemical and biophysical characterizations of cancer cells

KK Arafa, A Ibrahim, R Mergawy, IM El-Sherbiny… - Micromachines, 2022 - mdpi.com
Cancer is a worldwide leading cause of death, and it is projected that newly diagnosed
cases globally will reach 27.5 million each year by 2040. Cancers (malignant tumors), unlike …

Blebs promote cell survival by assembling oncogenic signalling hubs

AD Weems, ES Welf, MK Driscoll, FY Zhou… - Nature, 2023 - nature.com
Most human cells require anchorage for survival. Cell–substrate adhesion activates diverse
signalling pathways, without which cells undergo anoikis—a form of programmed cell death …

Apoptotic features in non-apoptotic processes

MA Savitskaya, II Zakharov, GE Onishchenko - Biochemistry (Moscow), 2022 - Springer
Apoptosis is the most thoroughly studied type of regulated cell death. Certain events, such
as externalization of phosphatidylserine (PS) into the outer leaflet of plasma membrane …

In Vitro Cell Death Mechanisms Induced by Dicoma anomala Root Extract in Combination with ZnPcS4 Mediated-Photodynamic Therapy in A549 Lung Cancer Cells

A Chota, BP George, H Abrahamse - Cells, 2022 - mdpi.com
Globally, lung cancer has remained the leading cause of morbidity and mortality in men and
women. To enhance photodynamic therapeutic effects in vitro, the present study was …

Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin

Y Gao, Z Wang, Q Hao, W Li, Y Xu, J Zhang… - Nature …, 2017 - nature.com
Oestrogen receptor alpha (ERα) is a well-known target of endocrine therapy for ERα-positive
breast cancer. ERα-negative cells, which are enriched during endocrine therapy, are …

[HTML][HTML] Apoptotic efficiency of Dicoma anomala biosynthesized silver nanoparticles against A549 lung cancer cells

A Chota, BP George, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Lung cancer is one of the common forms of cancer that affects both men and women and is
regarded as the leading cause of cancer related deaths. It is characterized by unregulated …

Overexpression of DAPK1-mediated inhibition of IKKβ/CSN5/PD-L1 axis enhances natural killer cell killing ability and inhibits tumor immune evasion in gastric cancer

Z Guo, C Zhou, L Zhou, Z Wang, X Zhu, X Mu - Cellular Immunology, 2022 - Elsevier
Gastric cancer (GC) originates from the stomach and is a prevalent human malignancy.
Dysfunction of death associated protein kinase 1 (DAPK1) has been identified as a major …

ATP-gated P2X7 receptors require chloride channels to promote inflammation in human macrophages

L Janks, RS Sprague, TM Egan - The Journal of Immunology, 2019 - journals.aai.org
Immune cells of myeloid origin show robust expression of ATP-gated P2X7 receptors, two-
transmembrane ion channels permeable to Na+, K+, and Ca 2+. Receptor activation …

Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl) ethyl]-1H-1, 2, 3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico …

VN Holanda, WV da Silva, PH do Nascimento… - Bioorganic …, 2020 - Elsevier
Organic compounds obtained by click chemistry reactions have demonstrated a broad
spectrum of biological activities being widely applied for the development of molecules …

KIF 13A‐regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration

X Gong, Y Didan, JG Lock, S Strömblad - The EMBO Journal, 2018 - embopress.org
Membrane blebbing‐dependent (blebby) amoeboid migration can be employed by
lymphoid and cancer cells to invade 3D‐environments. Here, we reveal a mechanism by …