The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer
immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell …

The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …

Pancreatic cancer is one of the most malignant tumors with increased incidence rate. The
effect of surgery combined with chemoradiotherapy on survival of patients is unsatisfactory …

Background We previously reported higher plasma levels of complement fragments C3a
and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular …

The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …

Numerous factors have been claimed to play important roles in colorectal cancer (CRC)
tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune …

Crosstalk of a tumor with its microenvironment is a critical factor contributing to cancer
development. This study investigates the soluble factors released by tumor-associated …

Colorectal cancer (CRC) is the third most common malignant tumor and the second most
fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer …

Genetic lesions predisposing to pediatric B-cell acute lymphoblastic leukemia (B-ALL) arise
in utero, generating a clinically silent pre-leukemic phase. We here reviewed the role of the …