The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …
preclinical models and clinical studies of depression have revealed an array of structural …
[HTML][HTML] Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus
Adverse events in early life can modulate the response to additional stressors later in life
and increase the risk of developing psychiatric disorders. The underlying molecular …
and increase the risk of developing psychiatric disorders. The underlying molecular …
[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use …
Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …
accompanied by a surge of overdose deaths. While opioid dependence has been …
[HTML][HTML] Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice
Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …
depression, which commonly arise following early life stress/adversity (ELA). However, how …
[HTML][HTML] Impact of early life stress on reward circuit function and regulation
Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …
[HTML][HTML] Multiomic profiling of the acute stress response in the mouse hippocampus
The acute stress response mobilizes energy to meet situational demands and re-establish
homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief …
homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief …
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons
Animals susceptible to chronic social defeat stress (CSDS) exhibit depression-related
behaviors, with aberrant transcription across several limbic brain regions, most notably in …
behaviors, with aberrant transcription across several limbic brain regions, most notably in …
[HTML][HTML] Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
[HTML][HTML] Genetic insights into the neurobiology of anxiety
MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
organism surviving threatening situations. Anxiety and vigilance states are regulated by …