Lipid-based DNA therapeutics: hallmarks of non-viral gene delivery

J Buck, P Grossen, PR Cullis, J Huwyler… - ACS …, 2019 - ACS Publications
Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral
gene delivery systems including lipid-based DNA therapeutics offer the opportunity to …

[HTML][HTML] The past, present, and future of breast cancer models for nanomedicine development

P Boix-Montesinos, PM Soriano-Teruel… - Advanced drug delivery …, 2021 - Elsevier
Even given recent advances in nanomedicine development of breast cancer treatment in
recent years and promising results in pre-clinical models, cancer nanomedicines often fail at …

Anionic lipid nanoparticles preferentially deliver mRNA to the hepatic reticuloendothelial system

R Pattipeiluhu, G Arias‐Alpizar, G Basha… - Advanced …, 2022 - Wiley Online Library
Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos

M Sun, R Ding, Y Ma, Q Sun, X Ren, Z Sun, J Duan - Chemosphere, 2021 - Elsevier
Environmental exposure to nanoplastics is inevitable as the application of nanoplastics in
our daily life is more and more extensively. So, the adverse effects of nanoplastics on human …

Are nano-pesticides really meant for cleaner production? An overview on recent developments, benefits, environmental hazards and future prospectives

N Rani, A Duhan, A Pal, P Kumari, RK Beniwal… - Journal of Cleaner …, 2023 - Elsevier
The world is seeking hard for sustainable agricultural practices with one of the prime
objectives to improve crop yield through effective pest management. Scientific diaspora has …

Current hurdles to the translation of nanomedicines from bench to the clinic

S Đorđević, MM Gonzalez, I Conejos-Sánchez… - Drug delivery and …, 2022 - Springer
The field of nanomedicine has significantly influenced research areas such as drug delivery,
diagnostics, theranostics, and regenerative medicine; however, the further development of …

Nanomaterials meet zebrafish: Toxicity evaluation and drug delivery applications

HR Jia, YX Zhu, QY Duan, Z Chen, FG Wu - Journal of Controlled Release, 2019 - Elsevier
With the rapid development of engineered nanomaterials for various applications, in vivo
toxicological studies for evaluating the potential hazardous effects of nanomaterials on …

Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

G Arias-Alpizar, L Kong, RC Vlieg, A Rabe… - Nature …, 2020 - nature.com
Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any
encapsulated contents, in vivo. Herein, we describe, and visualise in real time, light …

Metal–organic framework assisted and tumor microenvironment modulated synergistic image‐guided photo‐chemo therapy

Y Wang, W Wu, D Mao, C Teh… - Advanced Functional …, 2020 - Wiley Online Library
The complex tumor microenvironment (TME) and nonspecific drug targeting limit the clinical
efficacy of photodynamic therapy in combination with chemotherapy. Herein, a metal …

Zebrafish (Danio rerio) as an excellent vertebrate model for the development, reproductive, cardiovascular, and neural and ocular development toxicity study of …

C Shen, Z Zuo - Environmental Science and Pollution Research, 2020 - Springer
In the past decades, the type of chemicals has gradually increased all over the world, and
many of these chemicals may have a potentially toxic effect on human health. The zebrafish …