Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns

DEW Chatterton, DN Nguyen, SB Bering… - The international journal …, 2013 - Elsevier
The human newborn infant is susceptible to gut inflammatory disorders. In particular, growth-
restricted infants or infants born prematurely may develop a severe form of intestinal …

Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

Antibiotic treatment affects intestinal permeability and gut microbial composition in Wistar rats dependent on antibiotic class

MVL Tulstrup, EG Christensen, V Carvalho, C Linninge… - PloS one, 2015 - journals.plos.org
Antibiotics are frequently administered orally to treat bacterial infections not necessarily
related to the gastrointestinal system. This has adverse effects on the commensal gut …

Association between duration of early empiric antibiotics and necrotizing enterocolitis and late-onset sepsis in preterm infants: a multicenter cohort study

TH Dierikx, N Deianova, J Groen, DC Vijlbrief… - European journal of …, 2022 - Springer
The threshold to initiate empiric antibiotics for suspicion of early-onset sepsis (EOS) is low in
preterm infants. Antibiotics' effects on short-term outcomes have recently been debated. We …

Sepsis and oxidative stress in the newborn: from pathogenesis to novel therapeutic targets

C Poggi, C Dani - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
Sepsis is at present one of the leading causes of morbidity and mortality in the neonatal
population. Together with inflammation, oxidative stress is involved in detrimental pathways …

Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review

A Cuna, MJ Morowitz, V Sampath - Frontiers in Pediatrics, 2023 - frontiersin.org
While prompt initiation of antibiotics at birth due to concerns for early onset sepsis is
common, it often leads to many preterm infants being exposed to treatment despite negative …

Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges

P Lu, CP Sodhi, H Jia, S Shaffiey… - American Journal …, 2014 - journals.physiology.org
Necrotizing enterocolitis is the leading cause of morbidity and mortality from gastrointestinal
disease in premature infants and is characterized by initial feeding intolerance and …

Postnatal amniotic fluid intake reduces gut inflammatory responses and necrotizing enterocolitis in preterm neonates

J Siggers, MV Østergaard, RH Siggers… - American Journal …, 2013 - journals.physiology.org
Preterm neonates are susceptible to gastrointestinal disorders such as necrotizing
enterocolitis (NEC). Maternal milk and colostrum protects against NEC via growth promoting …

Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota

ME Arnal, JP Lalles - Nutrition reviews, 2016 - academic.oup.com
The epidemic of metabolic diseases has raised questions about the interplay between the
human diet and the gut and its microbiota. The gut has two vital roles: nutrient absorption …

Are antibiotics a risk factor for the development of necrotizing enterocolitis—case-control retrospective study

AA Raba, A O'Sullivan, J Semberova, A Martin… - European Journal of …, 2019 - Springer
Previous studies have identified numerous risk factors associated with necrotizing
enterocolitis (NEC) in very low birth weight (VLBW; birth weight less than 1500 g) infants …