An update on VEXAS syndrome

A Al-Hakim, S Savic - Expert Review of Clinical Immunology, 2023 - Taylor & Francis
Introduction VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome
is a recently described, late-onset, acquired autoinflammatory disorder caused by mutations …

Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment

LV Kovtonyuk, K Fritsch, X Feng, MG Manz… - Frontiers in …, 2016 - frontiersin.org
All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …

Estimated prevalence and clinical manifestations of UBA1 variants associated with VEXAS syndrome in a clinical population

DB Beck, DL Bodian, V Shah, UL Mirshahi, J Kim… - Jama, 2023 - jamanetwork.com
Importance VEXAS (vacuoles, E1-ubiquitin-activating enzyme, X-linked, autoinflammatory,
somatic) syndrome is a disease with rheumatologic and hematologic features caused by …

Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet

L Malcovati, E Hellström-Lindberg… - Blood, The Journal …, 2013 - ashpublications.org
Within the myelodysplastic syndrome (MDS) work package of the European LeukemiaNet,
an Expert Panel was selected according to the framework elements of the National Institutes …

Myelodysplastic syndromes

L Adès, R Itzykson, P Fenaux - The Lancet, 2014 - thelancet.com
Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …

Detectable clonal mosaicism from birth to old age and its relationship to cancer

CC Laurie, CA Laurie, K Rice, KF Doheny, LR Zelnick… - Nature …, 2012 - nature.com
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

Epidemiology of myelodysplastic syndromes: why characterizing the beast is a prerequisite to taming it

AM Zeidan, RM Shallis, R Wang, A Davidoff, X Ma - Blood reviews, 2019 - Elsevier
Myelodysplastic syndromes (MDS) consist of a heterogeneous group of myeloid neoplasms
characterized by inefficient hematopoiesis, variable cytopenias and a considerable risk of …

[HTML][HTML] Myelodysplastic syndromes: moving towards personalized management

E Hellström-Lindberg, M Tobiasson, P Greenberg - Haematologica, 2020 - ncbi.nlm.nih.gov
The myelodysplastic syndromes (MDS) share their origin in the hematopoietic stem cell but
have otherwise very heterogeneous biological and genetic characteristics. Clinical features …

Myelodysplastic syndromes: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†☆

P Fenaux, D Haase, V Santini, GF Sanz… - Annals of …, 2021 - annalsofoncology.org
Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell (HSC) disorders
predominating in the elderly, characterised by ineffective haematopoiesis leading to blood …

Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort

V Bach, G Schruckmayer, I Sam… - … interventions in aging, 2014 - Taylor & Francis
Background Anemia in later life is associated with increased morbidity and mortality. The
purpose of this study was to evaluate the prevalence and possible causes of anemia in the …