A natural products solution to diabetic nephropathy therapy

Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

[HTML][HTML] In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

GJ Shi, Y Li, QH Cao, HX Wu, XY Tang, XH Gao… - Biomedicine & …, 2019 - Elsevier
Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions,
including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly …

Schisandrin a from schisandra chinensis attenuates ferroptosis and NLRP3 inflammasome‐mediated pyroptosis in diabetic nephropathy through mitochondrial …

X Wang, Q Li, B Sui, M Xu, Z Pu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Schisandra chinensis, as a Chinese functional food, is rich in unsaturated fatty acids,
minerals, vitamins, and proteins. Hence, this study was intended to elucidate the effects and …

Pyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance

Y Liu, H Lei, W Zhang, Q Xing, R Liu, S Wu, Z Liu… - Cell Death & …, 2023 - nature.com
Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study

YY Gu, M Zhang, H Cen, YF Wu, Z Lu, F Lu, XS Liu… - PloS one, 2021 - journals.plos.org
Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with
SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with …

Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease

D Margină, A Ungurianu, C Purdel… - Food and chemical …, 2020 - Elsevier
Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular
disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non …

Relevance of the pyroptosis-related inflammasome pathway in the pathogenesis of diabetic kidney disease

P Liu, Z Zhang, Y Li - Frontiers in immunology, 2021 - frontiersin.org
Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) in many
developed and developing countries. Pyroptosis is a recently discovered form of …

A review of traditional Chinese medicine on treatment of diabetic nephropathy and the involved mechanisms

XJ Liu, XK Hu, H Yang, LM Gui, ZX Cai… - The American journal …, 2022 - World Scientific
Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus
(DM), which can lead to renal failure in diabetic patients. At present, the first-line drugs for …

Dihydroquercetin attenuates silica-induced pulmonary fibrosis by inhibiting ferroptosis signaling pathway

L Yuan, Y Sun, N Zhou, W Wu, W Zheng… - Frontiers in …, 2022 - frontiersin.org
Silicosis is a fatal occupational lung disease which currently has no effective treatment.
Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-inflammatory, anti …

Celastrol inhibits rheumatoid arthritis through the ROS-NF-κB-NLRP3 inflammasome axis

M Jing, J Yang, L Zhang, J Liu, S Xu, M Wang… - International …, 2021 - Elsevier
Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-
induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA) …