Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
Dopamine: the neuromodulator of long-term synaptic plasticity, reward and movement control
L Speranza, U Di Porzio, D Viggiano, A de Donato… - Cells, 2021 - mdpi.com
Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions
including motor control, modulation of affective and emotional states, reward mechanisms …
including motor control, modulation of affective and emotional states, reward mechanisms …
How to make a midbrain dopaminergic neuron
Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …
during recent years. This is due in part to a growing interest in regenerative medicine and …
Defined three-dimensional microenvironments boost induction of pluripotency
Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have
been explored to improve the original protocol, which is based on a two-dimensional (2D) …
been explored to improve the original protocol, which is based on a two-dimensional (2D) …
[HTML][HTML] Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development
SV Hegarty, AM Sullivan, GW O'keeffe - Developmental biology, 2013 - Elsevier
Dopaminergic (DA) neurons of the ventral midbrain (VM) play vital roles in the regulation of
voluntary movement, emotion and reward. They are divided into the A8, A9 and A10 …
voluntary movement, emotion and reward. They are divided into the A8, A9 and A10 …
Neuronal survival in the brain: neuron type-specific mechanisms
U Pfisterer, K Khodosevich - Cell death & disease, 2017 - nature.com
Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …
survive and reach a mature stage. Developmental cell death affects both embryonically …
miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
Although it is well established that embryonic stem (ES) cells have the potential to
differentiate into dopamine neurons, the molecular basis of this process, particularly the role …
differentiate into dopamine neurons, the molecular basis of this process, particularly the role …
Revisiting the expression of BDNF and its receptors in mammalian development
EE Esvald, J Tuvikene, CS Kiir, A Avarlaid… - Frontiers in Molecular …, 2023 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) promotes the survival and functioning of neurons
in the central nervous system and contributes to proper functioning of many non-neural …
in the central nervous system and contributes to proper functioning of many non-neural …
Brain‐derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β‐catenin signaling pathway
BY Chen, X Wang, ZY Wang, YZ Wang… - Journal of …, 2013 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) has critical functions in promoting survival,
expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation …
expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation …
Molecular insights into NR4A2 (Nurr1): an emerging target for neuroprotective therapy against neuroinflammation and neuronal cell death
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …