The interferons (IFNs) are a primary defense against pathogens because of the strong
antiviral activities they induce. IFNs can be classified into three groups: type I, type II and …

Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …

The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both
protective and harmful effects being documented. We report here a multiomics investigation …

Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable
levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and
resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic …

Dendritic cells (DCs) play important roles in orchestrating host immunity against invading
pathogens, representing one of the first responders to infection by mucosal invaders. From …

Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing
virus control versus immune-mediated pathologies, and have been successfully employed …

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the
donor quasispecies establishing the new infection. A critical, and as yet unresolved …

Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …