Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

Digital analysis of pathology whole-slide images is fast becoming a game changer in cancer
diagnosis and treatment. Specifically, deep learning methods have shown great potential to …

Circulating tumor DNA (ctDNA) enables real-time genomic profiling of cancer without the
need for tissue biopsy. ctDNA-based technology is seeing rapid uptake in clinical practice …

Driver gene mutations that are more prevalent in metastatic, castration-resistant prostate
cancer (mCRPC) than localized disease represent candidate prognostic biomarkers. We …

Many organs experience a loss of tissue mass and a decline in regenerative capacity during
aging. In contrast, the prostate continues to grow in volume. In fact, age is the most important …

We present SVclone, a computational method for inferring the cancer cell fraction of
structural variant (SV) breakpoints from whole-genome sequencing data. SVclone …

Large-scale tumor molecular profiling has revealed that diverse cancer histologies are
driven by common pathways with unifying biomarkers that can be exploited therapeutically …

Tumors are made of evolving and heterogeneous populations of cells which arise from
successive appearance and expansion of subclonal populations, following acquisition of …

Heterogeneity is a fundamental feature of human tumors and plays a major role in drug
resistance and disease progression. In the present study, we selected single-cell-derived …