Emerging evidence suggests that vascular pathological changes play a pivotal role in the
pathogenesis of Alzheimer's disease (AD). The dysfunction of the cerebral vasculature …

Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration
could identify individuals at risk for cognitive decline in Alzheimer's disease (AD). In blood …

Background Cognitive impairment is prevalent in patients with heart failure with reduced
ejection fraction (HFrEF), affecting self-care and outcomes. Novel blood-based biomarkers …

Over the last 50 years the different isoforms of tau proteins (45–60 kDa) have been a focus
of research because of their roles in modulating the dynamic properties of microtubules …

Background Tau, a microtubule-associated protein extensively distributed within the central
nervous system (CNS), exhibits close associations with various neurodegenerative …

Forensic institutions throughout the world house patients with severe psychiatric illness and
history of criminal violations. Improved medical care, hygiene, psychiatric treatment, and …

Lehtonen from the Helsinki University Central Hospital and University of Helsinki, and
colleagues. 1 The authors note that cardiac sarcoidosis (CS) results from epithelioid cell …

Tau is a microtubule associated protein that plays important roles in regulating the
properties of microtubules and axonal transport, as well as tauopathies associated with toxic …

The accumulation of the protein tau has long been associated with a number of
neurodegenerative diseases. Tau proteins were discovered in 1975 and were initially …

PUBLISHED BY ELSEVIER with the recently published first description of myocardial pTau
overexpression in HF hearts. 2 Mechanistically, phosphorylation of cardiac tau is thought to …