[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver
SO Jensen-Cody, MJ Potthoff - Molecular metabolism, 2021 - Elsevier
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease—the transition from an adipocentric to liver …
M Vesković, N Šutulović, D Hrnčić… - Current issues in …, 2023 - mdpi.com
The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …
[HTML][HTML] Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity
Abstract Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with
various side effects, including cardiovascular and hepatic disorders. Studies suggest that …
various side effects, including cardiovascular and hepatic disorders. Studies suggest that …
In a prediabetic model, empagliflozin improves hepatic lipid metabolism independently of obesity and before onset of hyperglycemia
M Hüttl, I Markova, D Miklankova, I Zapletalova… - International journal of …, 2021 - mdpi.com
Recent studies suggest that treatment with SGLT-2 inhibitors can reduce hepatic lipid
storage and ameliorate non-alcoholic fatty liver disease (NAFLD) development beyond their …
storage and ameliorate non-alcoholic fatty liver disease (NAFLD) development beyond their …
Molecular and pathobiological involvement of fetuin-A in the pathogenesis of NAFLD
The liver acts as a manufacturing unit for the production of fetuin-A, which is essential for
various physiological characteristics. Scientific research has shown that a moderate upward …
various physiological characteristics. Scientific research has shown that a moderate upward …
Fetuin-A: a relevant novel serum biomarker for non-invasive diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD): a retrospective case …
MM Elhoseeny, BA Abdulaziz, MA Mohamed… - BMC …, 2024 - Springer
Objectives To determine how fetuin-A contributes to diagnosing and assessing MASLD
severity. Methods Fifty MASLD patients and fifty healthy control participants were involved in …
severity. Methods Fifty MASLD patients and fifty healthy control participants were involved in …
Current understanding on pathogenesis and effective treatment of glycogen storage disease type Ib with empagliflozin: new insights coming from diabetes for its …
A Maiorana, F Tagliaferri, C Dionisi-Vici - Frontiers in Endocrinology, 2023 - frontiersin.org
Glycogen storage type Ib (GSDIb) is a rare inborn error of metabolism caused by glucose-6-
phosphate transporter (G6PT, SLC37A4) deficiency. G6PT defect results in excessive …
phosphate transporter (G6PT, SLC37A4) deficiency. G6PT defect results in excessive …
Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury in mouse
Edible and medicinal fungi are one of the major sources for extraction and identification of
polysaccharides, which are important biological response modifiers with notable antitumor …
polysaccharides, which are important biological response modifiers with notable antitumor …
Role of hepatokines in non-alcoholic fatty liver disease
Y Ke, C Xu, J Lin, Y Li - Journal of Translational Internal Medicine, 2019 - degruyter.com
Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases like
type 2 diabetes and obesity. In recent decades, accumulating evidence has revealed that …
type 2 diabetes and obesity. In recent decades, accumulating evidence has revealed that …
[HTML][HTML] SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation
Rationale: While some non-steroidal anti-inflammatory drugs (NSAIDs) are reported to
induce hepatic steatosis, the molecular mechanisms are poorly understood. This study …
induce hepatic steatosis, the molecular mechanisms are poorly understood. This study …