Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH,
and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose …

Methylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary
structures. Strongly related to other posttranscriptional modifications, methylation of different …

Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing array of complex
and chemically challenging reactions across all domains of life. Of approximately 114,000 of …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

The radical SAM enzymes—also referred to as the AdoMet radical enzymes—are a newly
identified enzyme superfamily1 capable of catalyzing radical chemistry similar to, but more …

Methylation is an essential and ubiquitous reaction that plays an important role in a wide
range of biological processes. Most biological methylations use S-adenosylmethionine …

Methylation of small molecules and macromolecules is crucial in metabolism, cell signaling,
and epigenetic programming and is most often achieved by S-adenosylmethionine (SAM) …

Many metabolic pathways and cellular processes occurring in most sub-cellular
compartments depend on the functioning of iron-sulfur (Fe-S) proteins, whose cofactors are …

Several unexpected reports of iron–sulphur clusters in nucleic acid binding proteins have
recently appeared in the literature. Once thought to be relatively rare in these systems, iron …

Bottromycins represent a promising class of antibiotics binding to the therapeutically
unexploited A-site of the bacterial ribosome. By inhibiting translation they are active against …