The intron–exon architecture of many eukaryotic genes raises the intriguing question of
whether this unique organization serves any function, or is it simply a result of the spread of …

Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

Background Ever since the discovery of'genes in pieces' and mRNA splicing in eukaryotes,
origin and evolution of spliceosomal introns have been considered within the conceptual …

In this work we review the current knowledge on the prehistory, origins, and evolution of
spliceosomal introns. First, we briefly outline the major features of the different types of …

So far, most methods for identifying sequences under selection based on comparative
sequence data have either assumed selectional pressures are the same across all branches …

Numerous previous studies have elucidated 2 surprising patterns of spliceosomal intron
evolution in diverse eukaryotes over the past roughly 100 Myr. First, rates of recent intron …

Research into the origins of introns is at a critical juncture in the resolution of theories on the
evolution of early life (which came first, RNA or DNA?), the identity of LUCA (the last …

Numerous eukaryotic proteins contain multiple domains. Certain domains show a tendency
to occur in diverse domain architectures and can be considered “promiscuous.” These …

Several contrasting scenarios have been proposed for the origin and evolution of
spliceosomal introns, a hallmark of eukaryotic genes. A comprehensive probabilistic model …

Background Eukaryotic protein-coding genes are interrupted by spliceosomal introns, which
are removed from transcripts before protein translation. Many facets of spliceosomal intron …