Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to
address the donor shortage as well as immunologic rejection attributed to cells in …
address the donor shortage as well as immunologic rejection attributed to cells in …
[HTML][HTML] Insights into the role of sialylation in cancer progression and metastasis
C Dobie, D Skropeta - British Journal of Cancer, 2021 - nature.com
Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …
[HTML][HTML] Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies
MLE Lundahl, S Fogli, PE Colavita… - RSC chemical …, 2021 - pubs.rsc.org
Protein aggregation in biotherapeutics has been identified to increase immunogenicity,
leading to immune-mediated adverse effects, such as severe allergic responses including …
leading to immune-mediated adverse effects, such as severe allergic responses including …
Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies
Over recent decades, therapeutic proteins have had widespread success in treating a
myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical …
myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical …
[HTML][HTML] Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content
The circulatory half-life of recombinant therapeutic proteins is an important pharmacokinetic
attribute because it determines the dosing frequency of these drugs, translating directly to …
attribute because it determines the dosing frequency of these drugs, translating directly to …
Biotechnological advances in the synthesis of modified chondroitin towards novel biomedical applications
D Cimini, E Bedini, C Schiraldi - Biotechnology Advances, 2023 - Elsevier
Chondroitin sulfate (CS) is a well-known glycosaminoglycan present in a large variety of
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …
[HTML][HTML] Glycosylation changes in prostate cancer progression
Prostate Cancer (PCa) is the most commonly diagnosed malignancy and second leading
cause of cancer-related mortality in men. With the use of next generation sequencing and …
cause of cancer-related mortality in men. With the use of next generation sequencing and …
[HTML][HTML] Sialylated immunoglobulin G: a promising diagnostic and therapeutic strategy for autoimmune diseases
D Li, Y Lou, Y Zhang, S Liu, J Li, J Tao - Theranostics, 2021 - ncbi.nlm.nih.gov
Human immunoglobulin G (IgG), especially autoantibodies, has major implications for the
diagnosis and management of a wide range of autoimmune diseases. However, some …
diagnosis and management of a wide range of autoimmune diseases. However, some …
The N-glycans of lactoferrin: more than just a sweet decoration
K Zlatina, SP Galuska - Biochemistry and Cell Biology, 2021 - cdnsciencepub.com
Nearly all extracellular proteins undergo post-translational modification with sugar chains
during their transit through the endoplasmic reticulum and the Golgi apparatus. These …
during their transit through the endoplasmic reticulum and the Golgi apparatus. These …
[HTML][HTML] Impact of Specific N-Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological Assays
J Schwestka, J König-Beihammer, YJ Shin… - Frontiers in Plant …, 2021 - frontiersin.org
The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the
virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing …
virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing …