Host-directed therapy against mycobacterium tuberculosis infections with diabetes mellitus
L Zhao, K Fan, X Sun, W Li, F Qin, L Shi, F Gao… - Frontiers in …, 2024 - frontiersin.org
Tuberculosis (TB) is caused by the bacterial pathogen Mycobacterium tuberculosis (MTB)
and is one of the principal reasons for mortality and morbidity worldwide. Currently …
and is one of the principal reasons for mortality and morbidity worldwide. Currently …
An Update to Novel Therapeutic Options for Combating Tuberculosis: Challenges and Future Prospectives
S Suresh, R Fatma Begum… - Current Pharmaceutical …, 2024 - benthamdirect.com
Drug repurposing is an ongoing and clever strategy that is being developed to eradicate
tuberculosis amid challenges, of which one of the major challenges is the resistance …
tuberculosis amid challenges, of which one of the major challenges is the resistance …
Atorvastatin improves sputum conversion and chest X-ray severity score
BACKGROUND: We report the results of a phase IIB study investigating the safety and
effectiveness of atorvastatin use with standard anti-TB drugs. METHODS: In this multicentre …
effectiveness of atorvastatin use with standard anti-TB drugs. METHODS: In this multicentre …
Fluvastatin Converts Human Macrophages into Foam Cells with Increased Inflammatory Response to Inactivated Mycobacterium tuberculosis H37Ra
MT Montero-Vega, J Matilla, E Bazán, D Reimers… - Cells, 2024 - mdpi.com
Cholesterol biosynthesis inhibitors (statins) protect hypercholesterolemic patients against
developing active tuberculosis, suggesting that these drugs could help the host to control the …
developing active tuberculosis, suggesting that these drugs could help the host to control the …
The effect of statins on the risk of anti-tuberculosis drug-induced liver injury among patients with active tuberculosis: A cohort study
CK Huang, JY Huang, CH Chang, SJ Tsai… - Journal of Microbiology …, 2024 - Elsevier
Background Tuberculosis (TB) remains prevalent worldwide, and anti-TB drugs are
associated with drug-induced liver injury (DILI). Statins have pleiotropic effects which may …
associated with drug-induced liver injury (DILI). Statins have pleiotropic effects which may …
Probing Dermal Immunity to Mycobacteria through a Controlled Human Infection Model
EC Church, E Bishop, A Fiore-Gartland, KKQ Yu… - …, 2024 - journals.aai.org
Cutaneous mycobacterial infections cause substantial morbidity and are challenging to
diagnose and treat. An improved understanding of the dermal immune response to …
diagnose and treat. An improved understanding of the dermal immune response to …
Fluvastatin Converts Human Macrophages into Pro-inflammatory Foam Cells with Therapeutic Potential in Tuberculosis
MT Montero-Vega, J Matilla, E Bazán, D Reimers… - 2023 - preprints.org
Cholesterol biosynthesis inhibitors (statins) protect hypercholesterolemic patients from
developing active tuberculosis, suggesting that these drugs could help the host to control the …
developing active tuberculosis, suggesting that these drugs could help the host to control the …