IL-17 cytokines and chronic lung diseases
IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …
Lung cell atlases in health and disease
TS Adams, A Marlier, N Kaminski - Annual Review of Physiology, 2023 - annualreviews.org
The human lung cellular portfolio, traditionally characterized by cellular morphology and
individual markers, is highly diverse, with over 40 cell types and a complex branching …
individual markers, is highly diverse, with over 40 cell types and a complex branching …
T cell apoptosis characterizes severe Covid-19 disease
S André, M Picard, R Cezar, F Roux-Dalvai… - Cell Death & …, 2022 - nature.com
Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
[HTML][HTML] National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-Host disease: IV. the 2020 highly morbid forms …
D Wolff, V Radojcic, R Lafyatis, R Cinar… - … and cellular therapy, 2021 - Elsevier
Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …
Pathological mechanism and targeted drugs of COPD
P Guo, R Li, TH Piao, CL Wang, XL Wu… - International Journal of …, 2022 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis, emphysema,
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …
Natural history and mechanisms of COPD
P Lange, E Ahmed, ZM Lahmar, FJ Martinez… - …, 2021 - Wiley Online Library
The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …
resulting from numerous interacting factors throughout the life cycle with smoking being the …
Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy
Cystic fibrosis is a multiorgan disease caused by impaired function of the cystic fibrosis
transmembrane conductance regulator (CFTR). Since the introduction of the CFTR …
transmembrane conductance regulator (CFTR). Since the introduction of the CFTR …
[HTML][HTML] Pericytes: The lung-forgotten cell type
AT Garrison, RE Bignold, X Wu, JR Johnson - Frontiers in physiology, 2023 - frontiersin.org
Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal
surface of microvessels, where they provide structural and biochemical support. Pericytes …
surface of microvessels, where they provide structural and biochemical support. Pericytes …
Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis
S Wang, W Rao, A Hoffman, J Lin, J Li, T Lin… - Science translational …, 2023 - science.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …
Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease
Epithelial cells are charged with protection at barrier sites, but whether this normally
beneficial response might sometimes become dysfunctional still needs definition. Here, we …
beneficial response might sometimes become dysfunctional still needs definition. Here, we …