In recent years, an increasing number of studies have shown that prokaryotes and
eukaryotes are armed with sophisticated mechanisms to restart stalled or collapsed …

Packaging of eukaryotic genome into chromatin is a major obstacle to cells encountering
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …

Eukaryotic cells have evolved highly orchestrated protein catabolic machineries responsible
for the timely and selective disposal of proteins and organelles, thereby ensuring amino acid …

DNA repair must take place in the context of chromatin, and chromatin modifications and
DNA repair are intimately linked. The study of double-strand break repair has revealed …

DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic
consequences for genome stability if not properly repaired. DSBs can be repaired by either …

Complete and faithful duplication of its entire genetic material is one of the essential
prerequisites for a proliferating cell to maintain genome stability. Yet, during replication DNA …

DNA combing is a powerful method developed by Bensimon and colleagues to stretch DNA
molecules on silanized glass coverslips. This technique provides a unique way to monitor …

The regulation of chromatin mobility in response to DNA damage is important for
homologous recombination in yeast. Anchorage reduces rates of recombination, whereas …

DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication.
The choice of the sister chromatid as the preferential repair template is critical for genome …

Histone modification regulates replication-coupled nucleosome assembly, DNA damage
repair, and gene transcription. Changes or mutations in factors involved in nucleosome …