Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Melanin-like nanoparticles were synthesized with size control through neutralization of
dopamine hydrochloride with NaOH, followed by spontaneous air oxidation of dopamine …

We studied the reaction mechanism of dopamine autoxidation using quantum chemical
methods. Unlike other biogenic amines important in the central nervous system, dopamine …

Oligomeric forms of amyloid aggregates have been detected in the brains and tissues of
patients suffering from neurodegenerative disorders such as Parkinson's disease, and it is …

Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia,
rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies …

α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease,
Lewy body dementia, and multiple system atrophy, but can also be found in other …

Parkinson's disease (PD) is characterized by selective and progressive degeneration of
dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by …

Parkinson's disease (PD) is primarily a movement disorder driven by the loss of dopamine‐
producing neurons in the substantia nigra (SN). Early identification of the oxidative …