Chronotherapy for hypertension

NP Bowles, SS Thosar, MX Herzig, SA Shea - Current hypertension …, 2018 - Springer
Abstract Purpose of Review Given the emerging knowledge that circadian rhythmicity exists
in every cell and all organ systems, there is increasing interest in the possible benefits of …

Blood pressure variability: assessment, predictive value, and potential as a therapeutic target

G Parati, JE Ochoa, C Lombardi, G Bilo - Current Hypertension Reports, 2015 - Springer
A large body of evidence has consistently supported the relationship between blood
pressure (BP) levels and the risk of cardiovascular complications. In recent years, several …

Dosing time matters

MD Ruben, DF Smith, GA FitzGerald, JB Hogenesch - Science, 2019 - science.org
Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study

RC Hermida, DE Ayala, A Mojón… - Chronobiology …, 2010 - Taylor & Francis
Clinical studies have documented morning-evening, administration-time differences of
several different classes of hypertension medications in blood pressure (BP)-lowering …

Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study

J Boggia, Y Li, L Thijs, TW Hansen, M Kikuya… - The Lancet, 2007 - thelancet.com
Background Few studies have formally compared the predictive value of the blood pressure
at night over and beyond the daytime value. We investigated the prognostic significance of …

Chronotherapy: circadian rhythms and their influence in cancer therapy

A Amiama-Roig, EM Verdugo-Sivianes, A Carnero… - Cancers, 2022 - mdpi.com
Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …

Circadian rhythms and cardiovascular health

F Portaluppi, R Tiseo, MH Smolensky, RC Hermida… - Sleep medicine …, 2012 - Elsevier
The functional organization of the cardiovascular system shows clear circadian rhythmicity.
These and other circadian rhythms at all levels of organization are orchestrated by a central …

Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: the Ohasama study

H Metoki, T Ohkubo, M Kikuya, K Asayama, T Obara… - …, 2006 - Am Heart Assoc
There is continuing controversy over whether the pattern of circadian blood pressure (BP)
variation that includes a nocturnal decline in BP and a morning pressor surge has …

Chronotherapy with low-dose aspirin for prevention of complications in pregnancy

DE Ayala, R Ucieda, RC Hermida - Chronobiology international, 2013 - Taylor & Francis
Preeclampsia and gestational hypertension are major contributors to perinatal morbidity and
mortality. Several studies aimed to test the effects of low-dose aspirin (ASA) in the …

2013 Ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension …

RC Hermida, MH Smolensky, DE Ayala… - Chronobiology …, 2013 - Taylor & Francis
Correlation between systolic (SBP) and diastolic (DBP) blood pressure (BP) level and target
organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is much greater …