Chronotherapy for hypertension
Abstract Purpose of Review Given the emerging knowledge that circadian rhythmicity exists
in every cell and all organ systems, there is increasing interest in the possible benefits of …
in every cell and all organ systems, there is increasing interest in the possible benefits of …
Blood pressure variability: assessment, predictive value, and potential as a therapeutic target
G Parati, JE Ochoa, C Lombardi, G Bilo - Current Hypertension Reports, 2015 - Springer
A large body of evidence has consistently supported the relationship between blood
pressure (BP) levels and the risk of cardiovascular complications. In recent years, several …
pressure (BP) levels and the risk of cardiovascular complications. In recent years, several …
Dosing time matters
Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …
Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study
RC Hermida, DE Ayala, A Mojón… - Chronobiology …, 2010 - Taylor & Francis
Clinical studies have documented morning-evening, administration-time differences of
several different classes of hypertension medications in blood pressure (BP)-lowering …
several different classes of hypertension medications in blood pressure (BP)-lowering …
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study
Background Few studies have formally compared the predictive value of the blood pressure
at night over and beyond the daytime value. We investigated the prognostic significance of …
at night over and beyond the daytime value. We investigated the prognostic significance of …
Chronotherapy: circadian rhythms and their influence in cancer therapy
A Amiama-Roig, EM Verdugo-Sivianes, A Carnero… - Cancers, 2022 - mdpi.com
Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …
and metabolism to anticipate changes in the environment. These fluctuations are controlled …
Circadian rhythms and cardiovascular health
F Portaluppi, R Tiseo, MH Smolensky, RC Hermida… - Sleep medicine …, 2012 - Elsevier
The functional organization of the cardiovascular system shows clear circadian rhythmicity.
These and other circadian rhythms at all levels of organization are orchestrated by a central …
These and other circadian rhythms at all levels of organization are orchestrated by a central …
Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: the Ohasama study
There is continuing controversy over whether the pattern of circadian blood pressure (BP)
variation that includes a nocturnal decline in BP and a morning pressor surge has …
variation that includes a nocturnal decline in BP and a morning pressor surge has …
Chronotherapy with low-dose aspirin for prevention of complications in pregnancy
DE Ayala, R Ucieda, RC Hermida - Chronobiology international, 2013 - Taylor & Francis
Preeclampsia and gestational hypertension are major contributors to perinatal morbidity and
mortality. Several studies aimed to test the effects of low-dose aspirin (ASA) in the …
mortality. Several studies aimed to test the effects of low-dose aspirin (ASA) in the …
2013 Ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension …
RC Hermida, MH Smolensky, DE Ayala… - Chronobiology …, 2013 - Taylor & Francis
Correlation between systolic (SBP) and diastolic (DBP) blood pressure (BP) level and target
organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is much greater …
organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is much greater …