Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Neuroblastoma is the most common extracranial solid tumor of children. Neuroblastoma
tumors derive from the neural crest and synthesize neurotransmitters including the …

The centrosome acts as the major microtubule-organizing center (MTOC) for cytoskeleton
maintenance in interphase and mitotic spindle assembly in vertebrate cells. It duplicates …

To assemble mitotic spindles, cells nucleate microtubules from a variety of sources including
chromosomes and centrosomes. We know little about how the regulation of microtubule …

Many protein kinases are activated by a conserved regulatory step involving T-loop
phosphorylation. Although there is considerable focus on kinase activator proteins, the …

The small GTPase Ran regulates the interaction of transport receptors with a number of
cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import …

Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main
microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been …