The mammalian immune system has innate and adaptive components, which cooperate to
protect the host against microbial infections. The innate immune system consists of …

Helminths are parasitic worms. They are the most common infectious agents of humans in
developing countries and produce a global burden of disease that exceeds better-known …

Sleep is considered an important modulator of the immune response. Thus, a lack of sleep
can weaken immunity, increasing organism susceptibility to infection. For instance, shorter …

Th cell access to primary B cell follicles is dependent on CXCR5. However, whether CXCR5
induction on T cells is sufficient in determining their follicular positioning has been unclear …

Our understanding of the importance of CD4+ T cells in orchestrating immune responses
has grown dramatically over the past decade. This lymphocyte family consists of diverse …

The transcription factors T-bet and Bcl-6 are required for the establishment of a T helper type
1 cell (TH1 cell) and follicular helper T cell (TFH cell) gene-expression profile, respectively …

The role of specialized follicular helper T (TFH) cells in the germinal center has become well
recognized, but it is less clear how effector T cells govern the extrafollicular response, the …

Abstract Follicular helper T (T FH) cells, defined by expression of the surface markers
CXCR5 and programmed death receptor-1 (PD-1) and synthesis of IL-21, require …

IL-17F and IL-17A are members of the IL-17 pro-inflammatory cytokine family. IL-17A has
been implicated in the pathogenesis of autoimmune diseases. IL-17F is a disulfide-linked …

T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T
cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) …