Non-coding RNA networks in cancer
E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018 - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …
programming and gene regulation during development as well as in health and …
Noncoding RNA s in disease
E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …
processes. In parallel, a rapidly growing number of studies has unravelled associations …
Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation
S Cremer, KM Michalik, A Fischer, L Pfisterer, N Jaé… - Circulation, 2019 - Am Heart Assoc
Background: The majority of the human genome comprises noncoding sequences, which
are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple …
are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple …
Regulatory RNAs in heart failure
CPC Gomes, B Schroen, GM Kuster, EL Robinson… - Circulation, 2020 - Am Heart Assoc
Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a
leading cause of mortality and disability despite significant efforts to improve treatments and …
leading cause of mortality and disability despite significant efforts to improve treatments and …
Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy
Vast parts of mammalian genomes encode for transcripts that are not further translated into
proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained …
proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained …
[HTML][HTML] Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury
Macrophage activation, ie, classical M1 and the alternative M2, plays a critical role in many
pathophysiological processes, such as inflammation and tissue injury and repair. Although …
pathophysiological processes, such as inflammation and tissue injury and repair. Although …
Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients
M Gast, BH Rauch, A Haghikia… - Cardiovascular …, 2019 - academic.oup.com
Aims Inflammation is a key driver of atherosclerosis and myocardial infarction (MI), and
beyond proteins and microRNAs (miRs), long noncoding RNAs (lncRNAs) have been …
beyond proteins and microRNAs (miRs), long noncoding RNAs (lncRNAs) have been …
Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE−/−mice
M Gast, BH Rauch, S Nakagawa… - Cardiovascular …, 2019 - academic.oup.com
Aims The immune system is considered a key driver of atherosclerosis, and beyond proteins
and microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in immune control …
and microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in immune control …
From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases
U Landmesser, W Poller, S Tsimikas… - European heart …, 2020 - academic.oup.com
Nucleic acid-based therapeutics are currently developed at large scale for prevention and
management of cardiovascular diseases (CVDs), since:(i) genetic studies have highlighted …
management of cardiovascular diseases (CVDs), since:(i) genetic studies have highlighted …