Bacterial virus forcing of bacterial O-antigen shields: lessons from Coliphages
AV Letarov - International Journal of Molecular Sciences, 2023 - mdpi.com
In most Gram-negative bacteria, outer membrane (OM) lipopolysaccharide (LPS) molecules
carry long polysaccharide chains known as the O antigens or O polysaccharides (OPS). The …
carry long polysaccharide chains known as the O antigens or O polysaccharides (OPS). The …
Bacterial synthetic biology: tools for novel drug discovery
Introduction Bacterial synthetic biology has provided powerful tools to revolutionize the drug
discovery process. These tools can be harnessed to generate bacterial novel …
discovery process. These tools can be harnessed to generate bacterial novel …
P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri
The discovery of clustered, regularly interspaced, short palindromic repeats (CRISPR) and
the Cas9 RNA-guided nuclease provides unprecedented opportunities to selectively kill …
the Cas9 RNA-guided nuclease provides unprecedented opportunities to selectively kill …
Tail-engineered phage P2 enables delivery of antimicrobials into multiple gut pathogens
Bacteriophages can be reprogrammed to deliver antimicrobials for therapeutic and
biocontrol purposes and are a promising alternative treatment to antimicrobial-resistant …
biocontrol purposes and are a promising alternative treatment to antimicrobial-resistant …
Interaction of bacteriophage P1 with an epiphytic Pantoea agglomerans strain—the role of the interplay between various mobilome elements
K Giermasińska-Buczek, J Gawor… - Frontiers in …, 2024 - frontiersin.org
P1 is a model, temperate bacteriophage of the 94 kb genome. It can lysogenize
representatives of the Enterobacterales order. In lysogens, it is maintained as a plasmid. We …
representatives of the Enterobacterales order. In lysogens, it is maintained as a plasmid. We …
An adenine/thymidine-rich region is integral to RepL-mediated DNA replication
The lytic replication of bacteriophage P1 requires RepL expression and the lytic stage origin,
oriL, which is postulated to be located within repL gene sequence. The exact sequence of …
oriL, which is postulated to be located within repL gene sequence. The exact sequence of …
Establishing new technologies for the development of targeted virotherapies
T Cunliffe - 2023 - orca.cardiff.ac.uk
Despite improvements in cancer treatments, there is still an unmet clinical need for effective
therapeutic agents that are highly tumour specific. Oncolytic viruses hold many …
therapeutic agents that are highly tumour specific. Oncolytic viruses hold many …