For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights
into human biology. Yeast and humans share several thousand genes despite …

Precision medicine strives for highly individualized treatments for disease under the notion
that each individual's unique genetic makeup and environmental exposures imprints upon …

Abstract The InParanoid database (http://InParanoid. sbc. su. se) provides a user interface to
orthologs inferred by the InParanoid algorithm. As there are now international efforts to …

The correlation of phenotypic outcomes with genetic variation and environmental factors is a
core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient …

Bridging the gap between genetic variations, environmental determinants, and phenotypic
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …

Major neuropsychiatric disorders are highly heritable, with mounting evidence suggesting
that these disorders share overlapping sets of molecular and cellular underpinnings. In the …

Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet
knowledge of the complete stress‐activated regulatory network as well as design principles …

Background NKX2-1 encodes a transcription factor with large impact on the development of
brain, lung and thyroid. Germline mutations of NKX2-1 can lead to dysfunction and …

Human genome-wide association studies (GWAS) have successfully identified thousands of
susceptibility loci for common diseases with complex genetic etiologies. Although the …

The discovery of toolkit genes, which are highly conserved genes that consistently regulate
the development of similar morphological phenotypes across diverse species, is one of the …