Asthma phenotypes: the evolution from clinical to molecular approaches
SE Wenzel - Nature medicine, 2012 - nature.com
Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …
The genetics of asthma and allergic disease: a 21st century perspective
Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …
and environmental contributions. Recent genome‐wide association studies (GWAS) and …
Maturation of the gut microbiome and risk of asthma in childhood
The composition of the human gut microbiome matures within the first years of life. It has
been hypothesized that microbial compositions in this period can cause immune …
been hypothesized that microbial compositions in this period can cause immune …
Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma
There have been reports of associations between cesarean section delivery and the risk of
childhood asthma, potentially mediated through changes in the gut microbiota. We followed …
childhood asthma, potentially mediated through changes in the gut microbiota. We followed …
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …
childhood, but the underlying mechanisms are poorly understood. We performed a genome …
Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial
Importance Observational studies have suggested that increased dietary vitamin D intake
during pregnancy may protect against wheezing in the offspring, but the preventive effect of …
during pregnancy may protect against wheezing in the offspring, but the preventive effect of …
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Children's Health Study (CHS) and HARBORS study … - Nature …, 2011 - nature.com
Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …
environmental factors. We performed a meta-analysis of North American genome-wide …
Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: a combined analysis of two randomized controlled trials
Background We recently published two independent randomized controlled trials of vitamin
D supplementation during pregnancy, both indicating a> 20% reduced risk of …
D supplementation during pregnancy, both indicating a> 20% reduced risk of …
Rhinovirus wheezing illness and genetic risk of childhood-onset asthma
M Çalışkan, YA Bochkov, E Kreiner-Møller… - … England Journal of …, 2013 - Mass Medical Soc
Background Both genetic variation at the 17q21 locus and virus-induced respiratory
wheezing illnesses are associated with the development of asthma. Our aim was to …
wheezing illnesses are associated with the development of asthma. Our aim was to …
Lung eQTLs to help reveal the molecular underpinnings of asthma
Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …
pulmonary diseases; however, the molecular mechanism underlying these associations are …