Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery
Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …
Polymeric Nanoparticles for Drug Delivery
MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
Recent advances in biodegradable and biocompatible synthetic polymers used in skin wound healing
R Xu, Y Fang, Z Zhang, Y Cao, Y Yan, L Gan, J Xu… - Materials, 2023 - mdpi.com
The treatment of skin wounds caused by trauma and pathophysiological disorders has been
a growing healthcare challenge, posing a great economic burden worldwide. The use of …
a growing healthcare challenge, posing a great economic burden worldwide. The use of …
[HTML][HTML] Hydrophilic polymers: Current trends and visions for the future
N Bayliss, BVKJ Schmidt - Progress in Polymer Science, 2023 - Elsevier
Hydrophilic polymers are a major class of polymers in polymer science. They are found in
broad range of applications from superabsorbers to drug-delivery. In recent years, a plethora …
broad range of applications from superabsorbers to drug-delivery. In recent years, a plethora …
Fluorinated Lipid Nanoparticles for Enhancing mRNA Delivery Efficiency
H Zhang, C Meng, X Yi, J Han, J Wang, F Liu, Q Ling… - ACS …, 2024 - ACS Publications
Lipid nanoparticles (LNPs), a nonviral nucleic acid delivery system, have shown vast
potential for vaccine development and disease treatment. LNPs assist mRNA to cross …
potential for vaccine development and disease treatment. LNPs assist mRNA to cross …
The Power of Action Plots: Unveiling Reaction Selectivity of Light‐Stabilized Dynamic Covalent Chemistry
SC Gauci, FE Du Prez, JO Holloway… - Angewandte Chemie …, 2023 - Wiley Online Library
Exploiting the optimum wavelength of reactivity for efficient photochemical reactions has
been well‐established based on the development of photochemical action plots. We herein …
been well‐established based on the development of photochemical action plots. We herein …
Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution
SDP Fielden - Journal of the American Chemical Society, 2024 - ACS Publications
Covalent polymers are versatile macromolecules that have found widespread use in society.
Contemporary methods of polymerization have made it possible to construct sequence …
Contemporary methods of polymerization have made it possible to construct sequence …
An overview of lipid constituents in lipid nanoparticle mRNA delivery systems
S Wu, L Lin, L Shi, S Liu - Wiley Interdisciplinary Reviews …, 2024 - Wiley Online Library
Abstract mRNA therapeutics have shown great potential for a broad spectrum of disease
treatment. However, the challenges of mRNA's inherent instability and difficulty in cellular …
treatment. However, the challenges of mRNA's inherent instability and difficulty in cellular …
Delivery of mRNA Vaccine with 1, 2‐Diesters‐Derived Lipids Elicits Fast Liver Clearance for Safe and Effective Cancer Immunotherapy
Y Xu, Y Hu, H Xia, S Zhang, H Lei, B Yan… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA) vaccine is explored as a promising strategy for cancer
immunotherapy, but the side effects, especially the liver‐related damage caused by LNP …
immunotherapy, but the side effects, especially the liver‐related damage caused by LNP …