The genetics and pathogenesis of CAKUT
CM Kolvenbach, S Shril, F Hildebrandt - Nature Reviews Nephrology, 2023 - nature.com
Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …
malformations that arise from defective kidney or urinary tract development and frequently …
Liver transplantation today: where we are now and where we are going
AS Bodzin, TB Baker - Liver Transplantation, 2018 - journals.lww.com
Liver transplantation was made a reality through the bravery, innovation, and persistence of
Dr. Thomas Starzl. His death in 2017, at the age of 90, makes us pause to consider how far …
Dr. Thomas Starzl. His death in 2017, at the age of 90, makes us pause to consider how far …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …
disease. We report a modified human kidney organoid system that generates thousands of …
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair
N Gupta, T Matsumoto, K Hiratsuka… - Science translational …, 2022 - science.org
Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a
basal state after tubular injury. When injury is overwhelming or repetitive, however, that …
basal state after tubular injury. When injury is overwhelming or repetitive, however, that …
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys
Defining cellular and molecular identities within the kidney is necessary to understand its
organization and function in health and disease. Here we demonstrate a reproducible …
organization and function in health and disease. Here we demonstrate a reproducible …
Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
The generation of organoids is one of the biggest scientific advances in regenerative
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …
[HTML][HTML] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …
19. To this, we here established a human kidney organoid model promoting early hallmarks …
A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells
Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …
kidney development, disease, and injury are studied. Current protocols are technically …
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
Current kidney organoids model development and diseases of the nephron but not the
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …