Biofilms as promoters of bacterial antibiotic resistance and tolerance

C Uruén, G Chopo-Escuin, J Tommassen… - Antibiotics, 2020 - mdpi.com
Multidrug resistant bacteria are a global threat for human and animal health. However, they
are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to …

Three faces of biofilms: a microbial lifestyle, a nascent multicellular organism, and an incubator for diversity

A Penesyan, IT Paulsen, S Kjelleberg… - npj Biofilms and …, 2021 - nature.com
Biofilms are organised heterogeneous assemblages of microbial cells that are encased
within a self-produced matrix. Current estimates suggest that up to 80% of bacterial and …

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

[HTML][HTML] Biofilms by bacterial human pathogens: Clinical relevance-development, composition and regulation-therapeutical strategies

A Schulze, F Mitterer, JP Pombo, S Schild - Microbial Cell, 2021 - ncbi.nlm.nih.gov
Notably, bacterial biofilm formation is increasingly recognized as a passive virulence factor
facilitating many infectious disease processes. In this review we will focus on bacterial …

Convergence of Biofilm Formation and Antibiotic Resistance in Acinetobacter baumannii Infection

S Roy, G Chowdhury, AK Mukhopadhyay… - Frontiers in …, 2022 - frontiersin.org
Acinetobacter baumannii (A. baumannii) is a leading cause of nosocomial infections as this
pathogen has certain attributes that facilitate the subversion of natural defenses of the …

Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics

D Lebeaux, JM Ghigo, C Beloin - Microbiology and Molecular …, 2014 - Am Soc Microbiol
Surface-associated microbial communities, called biofilms, are present in all environments.
Although biofilms play an important positive role in a variety of ecosystems, they also have …

Strategies for combating bacterial biofilm infections

H Wu, C Moser, HZ Wang, N Høiby… - International journal of …, 2015 - nature.com
Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living
environment, especially in the hostile environment. Under the protection of biofilm, microbial …

Biofilm control by interfering with c-di-GMP metabolism and signaling

X Liu, B Cao, L Yang, JD Gu - Biotechnology Advances, 2022 - Elsevier
Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the
life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small …

An overview of biofilm formation–combating strategies and mechanisms of action of antibiofilm agents

ST Asma, K Imre, A Morar, V Herman, U Acaroz… - Life, 2022 - mdpi.com
Biofilm formation on surfaces via microbial colonization causes infections and has become a
major health issue globally. The biofilm lifestyle provides resistance to environmental …

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

S Wagner, R Sommer, S Hinsberger, C Lu… - Journal of medicinal …, 2016 - ACS Publications
Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …