[HTML][HTML] Synergy of combining methionine restriction and chemotherapy: the disruptive next generation of cancer treatment
Y Kubota, Q Han, Y Aoki, N Masaki… - Cancer Diagnosis & …, 2023 - ncbi.nlm.nih.gov
All cancer cell types are methionine-addicted, which is termed the Hoffman effect. Cancer
cells, unlike normal cells, cannot survive without large amount of methionine. In general …
cells, unlike normal cells, cannot survive without large amount of methionine. In general …
Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal …
Y Aoki, Q Han, Y Tome, J Yamamoto, Y Kubota… - Frontiers in …, 2022 - frontiersin.org
Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman
Effect, is due to altered use of methionine for increased and aberrant transmethylation …
Effect, is due to altered use of methionine for increased and aberrant transmethylation …
Long-term stable disease in a rectal-cancer patient treated by methionine restriction with oral recombinant methioninase and a low-methionine diet
Y Kubota, Q Han, K Hamada, Y Aoki… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Rectal cancer is a recalcitrant disease with limited treatment options. Pre-
clinical studies have shown the efficacy of methionine restriction with a low-methionine diet …
clinical studies have shown the efficacy of methionine restriction with a low-methionine diet …
Methionine gamma lyase: Structure-activity relationships and therapeutic applications
Methionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the
conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. The enzyme …
conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. The enzyme …
Stage IV pancreatic cancer patient treated with FOLFIRINOX combined with oral methioninase: a highly-rare case with long-term stable disease
Y Kubota, Q Han, C Hozumi, N Masaki… - Anticancer …, 2022 - ar.iiarjournals.org
Background: Pancreatic cancer is one of the most recalcitrant cancers, and more effective
therapy is needed. Pre-clinical studies have shown that patient-derived orthotopic xenograft …
therapy is needed. Pre-clinical studies have shown that patient-derived orthotopic xenograft …
Superiority of [11C]methionine over [18F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer
Y Kubota, T Sato, C Hozumi, Q Han, Y Aoki… - International Journal of …, 2023 - mdpi.com
Positron emission tomography (PET) is widely used to detect cancers. The usual isotope for
PET imaging of cancer is [18F] deoxyglucose. The premise of using [18F] deoxyglucose is …
PET imaging of cancer is [18F] deoxyglucose. The premise of using [18F] deoxyglucose is …
Rapid reduction of CEA and stable metastasis in an NRAS-mutant rectal-cancer patient treated with FOLFIRI and bevacizumab combined with oral recombinant …
Y Kubota, Q Han, S Morinaga, T Tsunoda, RM Hoffman - in vivo, 2023 - iv.iiarjournals.org
Background/Aim: The choice of chemotherapy agents for RAS-mutant colorectal cancer is
limited, and prognosis is poor compared to RAS-wild-type colorectal cancer. The purpose of …
limited, and prognosis is poor compared to RAS-wild-type colorectal cancer. The purpose of …
Oncogenes and methionine addiction of cancer: Role of c-MYC
Y Aoki, Q Han, Y Kubota, N Masaki… - Cancer genomics & …, 2023 - cgp.iiarjournals.org
Abstract Background/Aim: Methionine addiction is a general and fundamental hallmark of
cancer cells, termed the Hoffman effect. Previously Vanhamme and Szpirer showed that …
cancer cells, termed the Hoffman effect. Previously Vanhamme and Szpirer showed that …
Recombinant methioninase decreased the effective dose of irinotecan by 15-fold against colon cancer cells: a strategy for effective low-toxicity treatment of colon …
M Sato, Q Han, Y Kubota, A Baranov… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Irinotecan (IRN), a topoisomerase I inhibitor and pro-drug of SN-38, is first-
line treatment of colon cancer as part of FOLFIRI and FOLFOXIRI combination …
line treatment of colon cancer as part of FOLFIRI and FOLFOXIRI combination …
Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer
M Miyake, K Miyake, Q Han, K Igarashi… - Biochemical and …, 2023 - Elsevier
Gastric cancer is highly malignant and recalcitrant to first line chemotherapies that include 5-
fluorouracil (5-FU). Cancer cells are addicted to methionine for their proliferation and …
fluorouracil (5-FU). Cancer cells are addicted to methionine for their proliferation and …