Background: Pramipexole is a dopamine full agonist approved for the treatment of
Parkinson's disease and restless legs syndrome. Its high affinity for the D3 receptor and …

Background Dopamine D 2-like agonists show promise as treatments for depression. They
are thought to act by enhancing reward learning; however, the mechanisms by which they …

Lamotrigine is an effective mood stabiliser, largely used for the management and prevention
of depression in bipolar disorder. The neuropsychological mechanisms by which lamotrigine …

Depression is a common and often recurrent illness with significant negative impact on a
global scale. Current antidepressants are ineffective for up to one third of people with …

Motivation allows us to energise actions when we expect reward and is reduced in
depression. This effect, termed motivational vigour, has been proposed to rely on central …

Abstract Background Patients with Parkinson's disease (PD) show impaired performance in
taste recognition tests, which suggests a possible dopaminergic influence on gustatory …

Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic
transmission and prefrontal-dependent cognitive function. However, its role in other …

The unpredictable payouts of random-ratio schedules are highly motivating. This is likely
due to the relationship between unexpected rewards and dopamine neurons, which release …