Molecular biology of steroid hormone synthesis

WL Miller - Endocrine reviews, 1988 - academic.oup.com
Introduction S TEROID hormones are familiar clinically and physiologically as regulators of
physiological processes. Five groups of steroid hormones are generally recognized …

Primary aldosteronism: changing definitions and new concepts of physiology and pathophysiology both inside and outside the kidney

M Stowasser, RD Gordon - Physiological reviews, 2016 - journals.physiology.org
In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

The Arabidopsis cytochrome P450 CYP707A encodes ABA 8′‐hydroxylases: key enzymes in ABA catabolism

T Kushiro, M Okamoto, K Nakabayashi… - The EMBO …, 2004 - embopress.org
The hormonal action of abscisic acid (ABA) in plants is controlled by the precise balance
between its biosynthesis and catabolism. In plants, ABA 8′‐hydroxylation is thought to play …

Ecdysteroid chemistry and biochemistry

R Lafont, C Dauphin-Villemant, JT Warren, H Rees - Insect endocrinology, 2012 - Elsevier
Publisher Summary This chapter focuses on the techniques used for ecdysteroid analysis
and the biosynthesis and metabolism of these hormones. Ecdysteroids could be defined …

Steroidogenic electron transport in adrenal cortex mitochondria

JD Lambeth, DW Seybert, JR Lancaster… - Molecular and cellular …, 1982 - Springer
The flavoprotein NADPH-adrenodoxin reductase and the iron sulfur protein adrenodoxin
function as a short electron transport chain which donates electrons one-at-a-time to adrenal …

11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α …

AC Swart, L Schloms, KH Storbeck, LM Bloem… - The Journal of steroid …, 2013 - Elsevier
Abstract 11β-Hydroxyandrostenedione (11OHA4), which is unique to the adrenal, was first
isolated from human adrenal tissue in the fifties. It was later shown in the sixties that 11β …

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: quantification of steroid intermediates and end products in H295R …

L Schloms, KH Storbeck, P Swart… - The Journal of steroid …, 2012 - Elsevier
The steroid hormone output of the adrenal gland is crucial in the maintenance of hormonal
homeostasis, with hormonal imbalances being associated with numerous clinical conditions …

[HTML][HTML] Molecular and clinical advances in congenital adrenal hyperplasia

WL Miller, LS Levine - The Journal of pediatrics, 1987 - Elsevier
The simplified scheme of adrenal steroidogenesis (Fig. 1) shows the series of enzymatic
steps required for the synthesis of aldosterone, cortisol, and the sex steroids. Decreased …

Functional zonation of the rat adrenal cortex: the development and maintenance

F Mitani - Proceedings of the Japan Academy, Series B, 2014 - jstage.jst.go.jp
The adrenal cortex of mammals consists of three concentric zones, ie, the zona glomerulosa
(zG), the zona fasciculata (zF), and the zona reticularis (zR), which secrete …

11β-Hydroxyandrostenedione: downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways

AC Swart, KH Storbeck - Molecular and cellular endocrinology, 2015 - Elsevier
Abstract 11β-Hydroxyandrostenedione (11OHA4), a major C19 steroid produced by the
adrenal, was first reported in the 1950s. Initially the subject of numerous studies, interest …