High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …

Splicing factor mutations are common among cancers, recently emerging as drivers of
myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however …

U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a multifunctional protein that plays a
crucial role in the regulation of RNA splicing during eukaryotic gene expression. U2AF1 …

Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within
all cancer types. In this review, we described the current state of understanding of how RNA …

Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …

U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an indispensable pre-mRNA splicing
factor in the early process of splicing. Recently, U2AF2 was reported as a novel candidate …

RNA recognition motifs (RRMs) play a pivotal role in RNA metabolism and the regulation of
gene expression. Owing to their plasticity and fuzziness, targeting RRM/RNA interfaces with …

Introduction RNA splicing is a pivotal step of eukaryotic gene expression during which the
introns are excised from the precursor (pre-) RNA and the exons are joined together to form …

RNA splicing is a biological process to generate mature mRNA (mRNA) by removing introns
and annexing exons in the nascent RNA transcript and is executed by a multiprotein …