Cell death is a key feature of neurological diseases, including stroke and neurodegenerative
disorders. Studies in a variety of ischemic/hypoxic mouse models demonstrate that poly …

Abstract Sirtuins (SIRT1 to-7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+, thus making them capable of sensing the cellular metabolic status …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) and its cleavage products regulate cell
viability and NF-kB activity when expressed in neurons. PARP-1 cleavage generates a 24 …

Abstract Bv8/prokineticin 2 (PK2) is a member of a bioactive family of peptides that regulate
multiple functions in the CNS including hyperalgesia, neurogenesis, neuronal survival and …

An excessive activation of poly (ADP-ribose) polymerases (PARPs) may trigger a form of
neuronal death similar to that occurring in neurodegenerative disorders. To investigate this …

Chronic pain and depression often coexist sharing common pathological mechanisms, and
available analgesics and antidepressants have demonstrated limited clinical efficacy …

Intense poly (ADP-ribose) polymerase-1 (PARP-1) activation was implicated as a major
cause of caspase-independent cell death in the hippocampal neuronal culture (HNC) model …

Olaparib was the first poly (ADP-ribose) polymerase inhibitor approved by Food and Drug
Administration for oncology treatment. However, its neuroprotective effects have not been …

The prokineticin (PK) family, prokineticin 1 and Bv8/prokineticin 2 (PROK2), initially
discovered as regulators of gastrointestinal motility, interacts with two G protein-coupled …

Background Plant secondary metabolites may induce adaptive cellular stress-responses in
a variety of cells including neurons at the sub-toxic doses ingested by humans. Such …