Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell
adhesion. The Rho GTPases play key roles in coordinating the cellular responses required …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important
roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with …

Spermiation is the process by which mature spermatids are released from Sertoli cells into
the seminiferous tubule lumen prior to their passage to the epididymis. It takes place over …

Since 1982, Ras has been the subject of intense research scrutiny, focused on determining
the role of aberrant Ras function in human cancers and defining the mechanism by which …

United Kingdom(Zheng et al., 1995). In S. pombe, normal cell morphology is dependent on
both ras1 and cdc42 functions and genetic and biochemical analysis has revealed that ras1 …