Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

The evolution of novel morphological features, such as feathers, involves the modification of
developmental processes regulated by gene networks. The fact that genetic novelty …

The most conserved part of the vertebrate dopaminergic system is the orthopedia (otp)-
expressing diencephalic neuronal population that constitutes the dopaminergic …

We report the expression pattern and construction of a transgenic zebrafish line for a
transcription factor involved in otic vesicle formation and skeletogenesis. The zinc finger …

The discovery of the FOXP2 transcription factor, and its implication in a rare severe human
speech and language disorder, has led to two decades of empirical studies focused on …

Background Although the vertebrate skeleton arose in the sea 500 million years ago, our
understanding of the molecular fingerprints of chondrocytes and osteoblasts may be biased …

Highlights•FoxP2 is differentially expressed during development and singing behavior.•First
upstream factors and downstream targets of FoxP2 are identified.•FoxP2 affects …

Background The vertebrate craniofacial skeleton may exhibit anatomical complexity and
diversity, but its genesis and evolution can be understood through careful dissection of …