[HTML][HTML] Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

[HTML][HTML] Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Antibiotic adjuvants: a versatile approach to combat antibiotic resistance

G Dhanda, Y Acharya, J Haldar - ACS omega, 2023 - ACS Publications
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

[HTML][HTML] Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

A Gaurav, P Bakht, M Saini, S Pandey… - …, 2023 - microbiologyresearch.org
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Chiral sulfur nanosheets for dual-selective inhibition of gram-positive bacteria

X Huang, C Lu, W Zhang, L Liu, Z Zha, Z Miao - ACS nano, 2023 - ACS Publications
Elemental sulfur is the oldest known antimicrobial agent. However, conventional sulfur in the
clinic suffers from poor aqueous solubility and limited antibacterial activity, greatly hindering …

Antimicrobial hydrogels: potential materials for medical application

Y Li, Y Han, H Li, X Niu, D Zhang, K Wang - Small, 2024 - Wiley Online Library
Microbial infections based on drug‐resistant pathogenic organisms following surgery or
trauma and uncontrolled bleeding are the main causes of increased mortality from trauma …

Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

[HTML][HTML] Acinetobacter baumannii in the critically ill: complex infections get complicated

I Cavallo, A Oliva, R Pages, F Sivori, M Truglio… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

Recent advances on emerging biosensing technologies and on-site analytical devices for detection of drug-resistant foodborne pathogens

M Qiu, M Zheng, J Zhang, X Yang, Y Zhang… - TrAC Trends in …, 2023 - Elsevier
The emergence and prevalence of drug-resistant foodborne pathogens have posed a great
threat to food safety and public health. Therefore, rapid, sensitive, reliable, and on-site …

CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance

A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …