Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Animal experimentation in the Parkinson's disease (PD) field is a classic example of how the
use of animal models to study diseases can have a significant impact on human health …

Considerable progress has been made in generating fully functional and transplantable
dopamine neurons from human embryonic stem cells (hESCs). Before these cells can be …

A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Human idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder
that is primarily characterized by degeneration of the dopaminergic neurons of the …

Recombinant adeno-associated viral vectors display efficient tropism for transduction of the
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …

Misfolding and aggregation of α-synuclein are specific features of Parkinson's disease and
other neurodegenerative diseases defined as synucleinopathies. Parkinson's disease …

Most acute and chronic neurodegenerative conditions are accompanied by
neuroinflammation; yet the exact nature of the inflammatory processes and whether they …