Biomolecular simulation is increasingly central to understanding and designing biological
molecules and their interactions. Detailed, physics‐based simulation methods are …

The telomeric end structures of the DNA are known to contain tandem repeats of TTAGGG
sequence bound with specialised protein complex called the" shelterin complex". It …

Background: Alcoholic liver disease (ALD) is a progressive disease beginning with simple
steatosis but can progress to alcoholic steatohepatitis, fibrosis, cirrhosis, and even …

Molecular dynamics simulations of the Caenorhabditis elegans transcription factor SKN-1
bound to its cognate DNA site show that the protein–DNA interface undergoes significant …

The role of low frequency variants associated with telomere length homeostasis in chronic
diseases and mortalities is relatively understudied in the East-Asian population. Here we …

Previous research has shown that the major toxicity mechanism for many environment
chemicals is binding with estrogen receptor (ER) and blocking endogenous estrogen …

Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous
system. These receptors have emerged as therapeutic targets in drug discovery for treating …

Abstract Activator proteins 1 (AP-1) comprise one of the largest families of eukaryotic basic
leucine zipper transcription factors. Despite advances in the characterization of AP-1 DNA …

Despite a number of biochemical and lifestyle differences which should increase risk of
oxidative damage to their mitochondrial DNA (mtDNA) and thus reduce expected lifespan …

We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc
finger modules and an AT-hook linking peptide. The computational study provides for the …