The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …

Histone post-translational modifications regulate transcription and other DNA-templated
functions. This process is dynamically regulated by specific modifying enzymes whose …

The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor
(HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the …

Tissue homeostasis is dependent on the controlled localization of specific cell types and the
correct composition of the extracellular stroma. While the role of the cancer stroma in tumour …

Long noncoding (lnc) RNAs are a group of RNAs with a length greater than 200 nt that do
not encode a protein but play an essential role in regulating the expression of target genes …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …

High aerobic glycolysis not only provides energy to cancer cells, but also supports their
anabolic growth. JMJD1A, a histone demethylase that specifically demethylates …

The histone demethylase JMJD1A, which controls gene expression by epigenetic regulation
of H3K9 methylation marks, functions in diverse activities, including spermatogenesis …

Epigenetic changes are one underlying cause for cancer development and often due to
dysregulation of enzymes modifying DNA or histones. Most Jumonji C domain-containing …

Endocrine therapy has successfully been used to treat estrogen receptor (ER)-positive
breast cancer, but this invariably fails with cancers becoming refractory to treatment …