Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Heat stress is one of the most stressful events in the life of livestock with harmful
consequences for animal health, productivity and product quality. Ruminants, pigs and …

Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis)
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

The eukaryotic cell is morphologically and functionally organized as an interconnected
network of organelles that responds to stress and aging. Organelles communicate via …

Small heat shock proteins (sHSPs) are ATP-independent chaperones that delay formation of
harmful protein aggregates. sHSPs' role in protein homeostasis has been appreciated for …

Proteins are constantly challenged by environmental stress conditions that threaten their
structure and function. Especially problematic are oxidative, acid, and severe heat stress …

To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …

Small heat shock proteins (sHsps) bind unfolding proteins, thereby playing a pivotal role in
the maintenance of proteostasis in virtually all living organisms. Structural elucidation of …