Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

Ion channels are crucial components of cellular excitability and are involved in many
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …

We address advances in the understanding of myometrial physiology, focusing on excitation
and the effects of gestation on ion channels and their relevance to labor. This review moves …

The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …

Conspectus Sodium ion channels selectively transport Na+ cations across the cell
membrane. These integral parts of the cell machinery are implicated in regulating the …

Multicellularity has evolved multiple times, but animals are the only multicellular lineage with
nervous systems. This fact implies that the origin of nervous systems was an unlikely event …

NALCN, a sodium leak channel expressed mainly in the central nervous system, is
responsible for the resting Na+ permeability that controls neuronal excitability. Dysfunctions …

Electrical signaling is essential for all fast processes in biology, but its molecular
mechanisms have been uncertain. This review article focuses on studies of bacterial sodium …

How nature discriminates sodium from calcium ions in eukaryotic channels has been difficult
to resolve because they contain four homologous, but markedly different repeat domains …

Voltage-gated ion channels are important drug targets because they play crucial
physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs …