The role of circulating biomarkers in peripheral arterial disease

G Saenz-Pipaon, E Martinez-Aguilar, J Orbe… - International Journal of …, 2021 - mdpi.com
Peripheral arterial disease (PAD) of the lower extremities is a chronic illness predominantly
of atherosclerotic aetiology, associated to traditional cardiovascular (CV) risk factors. It is …

The role of neutrophils in lower limb peripheral artery disease: state of the art and future perspectives

G Buso, E Faggin, N Rosenblatt-Velin… - International Journal of …, 2023 - mdpi.com
In recent years, increasing attention has been paid to the role of neutrophils in
cardiovascular (CV) disease (CVD) with evidence supporting their role in the initiation …

Prdm16 supports arterial flow recovery by maintaining endothelial function

S Craps, J Van Wauwe, S De Moudt… - Circulation …, 2021 - Am Heart Assoc
Rationale: Understanding the mechanisms that regulate arterial flow recovery is important to
design treatment options for peripheral artery disease patients ineligible for invasive …

Ionizing radiation induces BH4 deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis

T Yan, T Zhang, W Mu, Y Qi, S Guo, N Hu… - Biochemical …, 2020 - Elsevier
Radiation enteritis (RE) is a common side effect after radiotherapy for abdominal cancer. RE
pathogenesis is complicated, with no drugs available for prevention or treatments. Intestinal …

Exposure of endothelium to biomimetic flow waveforms yields identification of miR-199a-5p as a potent regulator of arteriogenesis

JL Heuslein, CM Gorick, SP McDonnell, J Song… - … Therapy-Nucleic Acids, 2018 - cell.com
Arteriogenesis, the growth of endogenous collateral arteries bypassing arterial occlusion (s),
is a fundamental shear stress-induced adaptation with implications for treating peripheral …

Quantifying the vascular response to ischemia with speckle variance optical coherence tomography

KM Poole, DR McCormack, CA Patil… - Biomedical optics …, 2014 - opg.optica.org
Longitudinal monitoring techniques for preclinical models of vascular remodeling are critical
to the development of new therapies for pathological conditions such as ischemia and …

Epigenetic regulators of the revascularization response to chronic arterial occlusion

JL Heuslein, CM Gorick, RJ Price - Cardiovascular Research, 2019 - academic.oup.com
Peripheral arterial disease (PAD) is the leading cause of lower limb amputation and
estimated to affect over 202 million people worldwide. PAD is caused by atherosclerotic …

Endothelial-specific EphA4 negatively regulates native pial collateral formation and re-perfusion following hindlimb ischemia

B Okyere, K Giridhar, A Hazy, M Chen, D Keimig… - PLoS …, 2016 - journals.plos.org
Leptomeningeal anastomoses play a critical role in regulating vascular re-perfusion
following obstruction, however, the mechanisms regulating their development remains …

Dynamic multiscale regulation of perfusion recovery in experimental peripheral arterial disease: a mechanistic computational model

C Zhao, JL Heuslein, Y Zhang, BH Annex… - Basic to Translational …, 2022 - jacc.org
In peripheral arterial disease (PAD), the degree of endogenous capacity to modulate
revascularization of limb muscle is central to the management of leg ischemia. To …

MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis

JL Heuslein, SP McDonnell, J Song… - … in Bioengineering and …, 2018 - frontiersin.org
The growth of endogenous collateral arteries that bypass arterial occlusion (s), or
arteriogenesis, is a fundamental shear stress-induced adaptation with implications for …