The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …

The receptors through which serotonin (5-hydroxytryptamine, 5-HT) produces its effects
have been the subject of intense investigation, initially using both in vivo and in vitro …

Abstract The 5‐HT1A and 5‐HT1B receptors of serotonin play important roles as auto‐and
heteroreceptors controlling the release of serotonin itself and of other neurotransmitters …

The murine G-protein α-subunit Gα 15 and its human counterpart Gα 16 are expressed in a
subset of hematopoietic cells, and they have been shown to regulate β-isoforms of inositide …

Determination of the structure of integral membrane proteins is a challenging task that is
essential to understand how fundamental biological processes (such as photosynthesis …

There is a continued and growing interest in the classification of 5-HT receptors, partly
because of the enormous potential for exploiting this information in terms of drug discovery' …

Seven-helix membrane proteins represent a challenge for structural biology. Here we report
the first NMR structure determination of a detergent-solubilized seven-helix transmembrane …

The 5‐hydroxytryptamine 5‐HT1A receptor was one of the first G protein coupled receptors
whose cDNA and gene were isolated by molecular cloning methods. Transfection of the …

Serotonin is an intrinsically fluorescent biogenic amine that acts as a neurotransmitter and is
found in a wide variety of sites in the central and peripheral nervous system. Serotonergic …

G-protein-coupled receptors (GPCRs) are of prime importance for cell signal transduction
mechanisms and are the target of many current and potential drugs. However, structural …