Fetal programming of skeletal muscle development in ruminant animals

M Du, J Tong, J Zhao, KR Underwood… - Journal of animal …, 2010 - academic.oup.com
Enhancing skeletal muscle growth is crucial for animal agriculture because skeletal muscle
provides meat for human consumption. An increasing body of evidence shows that the level …

Intrauterine programming of obesity and type 2 diabetes

DS Fernandez-Twinn, L Hjort, B Novakovic, SE Ozanne… - Diabetologia, 2019 - Springer
The type 2 diabetes epidemic and one of its predisposing factors, obesity, are major
influences on global health and economic burden. It is accepted that genetics and the …

I'm eating for two: parental dietary effects on offspring metabolism

OJ Rando, RA Simmons - Cell, 2015 - cell.com
It has long been understood that the pathogenesis of complex diseases such as diabetes
includes both genetic and environmental components. More recently, it has become clear …

Sex differences in the intergenerational inheritance of metabolic traits

I Sandovici, DS Fernandez-Twinn, A Hufnagel… - Nature …, 2022 - nature.com
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

Mechanisms involved in the developmental programming of adulthood disease

MJ Warner, SE Ozanne - Biochemical Journal, 2010 - portlandpress.com
There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease

GC Burdge, KA Lillycrop - Annual review of nutrition, 2010 - annualreviews.org
There is considerable evidence for induction of differential risk of noncommunicable
diseases in humans by variation in the quality of the early life environment. Studies in animal …

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM

R Barrès, JR Zierath - Nature Reviews Endocrinology, 2016 - nature.com
Epigenetic changes are caused by biochemical regulators of gene expression that can be
transferred across generations or through cell division. Epigenetic modifications can arise …

A low maternal protein diet during pregnancy and lactation has sex‐and window of exposure‐specific effects on offspring growth and food intake, glucose metabolism …

E Zambrano, CJ Bautista, M Deas… - The Journal of …, 2006 - Wiley Online Library
Extensive epidemiological and experimental evidence indicates that a sub‐optimal
environment during fetal and neonatal development in both humans and animals may …

Developmental origins of adult disease

SC Langley-Evans, S McMullen - Medical principles and practice, 2010 - karger.com
Variation in the quality or quantity of nutrients consumed during pregnancy can exert
permanent and powerful effects upon the developing fetus. This programming of fetal …

Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and …

E Zambrano, PM Martinez‐Samayoa… - The Journal of …, 2005 - Wiley Online Library
Compelling epidemiological and experimental evidence indicates that a suboptimal
environment during fetal and neonatal development in both humans and animals may …