Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions

D Tesei, A Jewczynko, AM Lynch, C Urbaniak - Life, 2022 - mdpi.com
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

J Park, EG Overbey, SA Narayanan, JK Kim… - Nature …, 2024 - nature.com
Spaceflight can change metabolic, immunological, and biological homeostasis and cause
skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact …

Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

BT Tierney, JK Kim, EG Overbey, KA Ryon, J Foox… - Nature …, 2024 - nature.com
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Real-time culture-independent microbial profiling onboard the international space station using nanopore sequencing

S Stahl-Rommel, M Jain, HN Nguyen, RR Arnold… - Genes, 2021 - mdpi.com
For the past two decades, microbial monitoring of the International Space Station (ISS) has
relied on culture-dependent methods that require return to Earth for analysis. This has a …

Investigation of spaceflight induced changes to astronaut microbiomes

MD Morrison, JB Thissen, F Karouia, S Mehta… - Frontiers in …, 2021 - frontiersin.org
The International Space Station (ISS) is a uniquely enclosed environment that has been
continuously occupied for the last two decades. Throughout its operation, protecting the …

The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies

S Etlin, J Rose, L Bielski, C Walter… - Clinical Microbiology …, 2024 - journals.asm.org
The human microbiota encompasses the diverse communities of microorganisms that reside
in, on, and around various parts of the human body, such as the skin, nasal passages, and …

The indoors microbiome and human health

JA Gilbert, EM Hartmann - Nature Reviews Microbiology, 2024 - nature.com
Indoor environments serve as habitat for humans and are replete with various reservoirs and
niches for microorganisms. Microorganisms enter indoor spaces with their human and non …

Microbial Tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station

C Urbaniak, MD Morrison, JB Thissen, F Karouia… - Microbiome, 2022 - Springer
Abstract Background The International Space Station (ISS) is a unique and complex built
environment with the ISS surface microbiome originating from crew and cargo or from life …