Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …

Melatonin is a pleiotropic hormone with several functions. It binds to specific receptors and
to a number of cytosolic proteins, activating a vast array of signalling pathways. Its potential …

Mitochondrial dysfunction is linked with myocardial infarction (MI), a disorder in which
Notch1 has attracted increasing attention. However, the involvement of Notch1 in …

Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to
pump sufficient blood to the body. Despite recent advances in medical management, poor …

Mitochondrial dysfunction leads to reactive oxygen species (ROS) overload, exacerbating
injury in myocardial infarction (MI). As a receptor for translocases in the outer mitochondrial …

Cardiovascular diseases (CVDs) are the leading global cause of mortality and disability,
tending to happen in younger individuals in developed countries. Despite improvements in …

Blood–brain barrier (BBB) dysfunction is considered to be an early event in the
pathogenesis of a variety of neurological diseases in old patients, and this could occur in old …

Left ventricular hypertrophy (LVH) can be adaptive, as arising from exercise, or pathological,
most commonly when driven by hypertension. The pathophysiology of LVH is consistently …

Myocardial ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality
worldwide. Caveolae, caveolin-1 (Cav-1), and caveolin-3 (Cav-3) are essential for the …

Melatonin is well known for its cardioprotective effects; however, whether melatonin exerts
therapeutic effects on cardiomyocyte hypertrophy remains to be investigated, as do the …