Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria
H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …
community medical resources. As a result of the increasing prevalence of multidrug-resistant …
Phage-encoded endolysins
F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …
Potential for bacteriophage endolysins to supplement or replace antibiotics in food production and clinical care
There is growing concern about the emergence of bacterial strains showing resistance to all
classes of antibiotics commonly used in human medicine. Despite the broad range of …
classes of antibiotics commonly used in human medicine. Despite the broad range of …
Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy
Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents,
especially against multi-drug resistant pathogens. Herein we present a review about the …
especially against multi-drug resistant pathogens. Herein we present a review about the …
Phage lysins for fighting bacterial respiratory infections: a new generation of antimicrobials
Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5
million people each year and are the main causes of mortality in children under 5 years of …
million people each year and are the main causes of mortality in children under 5 years of …
[HTML][HTML] Bacteriophage-encoded enzymes destroying bacterial cell membranes and walls, and their potential use as antimicrobial agents
Ł Grabowski, K Łepek, M Stasiłojć… - Microbiological …, 2021 - Elsevier
Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …
one of the most significant medical problems. Therefore, development of novel antibacterial …
Advanced engineering of third-generation lysins and formulation strategies for clinical applications
V De Maesschalck, D Gutiérrez… - Critical reviews in …, 2020 - Taylor & Francis
One of the possible solutions for the current antibiotic resistance crisis may be found in
(often bacteriophage-derived) peptidoglycan hydrolases. The first clinical trials of these …
(often bacteriophage-derived) peptidoglycan hydrolases. The first clinical trials of these …
Evaluation of Phage Therapy in the Context of Enterococcus faecalis and Its Associated Diseases
AS Bolocan, A Upadrasta, PH de Almeida Bettio… - Viruses, 2019 - mdpi.com
Bacteriophages (phages) or bacterial viruses have been proposed as natural antimicrobial
agents to fight against antibiotic-resistant bacteria associated with human infections …
agents to fight against antibiotic-resistant bacteria associated with human infections …
An enterococcal phage-derived enzyme suppresses graft-versus-host disease
K Fujimoto, T Hayashi, M Yamamoto, N Sato… - Nature, 2024 - nature.com
Abstract Changes in the gut microbiome have pivotal roles in the pathogenesis of acute graft-
versus-host disease (aGVHD) after allogenic haematopoietic cell transplantation (allo …
versus-host disease (aGVHD) after allogenic haematopoietic cell transplantation (allo …
The clinical path to deliver encapsulated phages and lysins
AM Pinto, MD Silva, LM Pastrana… - FEMS Microbiology …, 2021 - academic.oup.com
The global emergence of multidrug-resistant pathogens is shaping the current dogma
regarding the use of antibiotherapy. Many bacteria have evolved to become resistant to …
regarding the use of antibiotherapy. Many bacteria have evolved to become resistant to …